THE GROWTH-ASSOCIATED PROTEIN-B-50 (GAP-43) IN DYSTROPHIC NEURITES EXTENDING INTO ALZHEIMERS PLAQUES

Authors
OESTREICHER AB ROZEMULLER JM GISPEN WH
Citation
Ab. Oestreicher et al., THE GROWTH-ASSOCIATED PROTEIN-B-50 (GAP-43) IN DYSTROPHIC NEURITES EXTENDING INTO ALZHEIMERS PLAQUES, Neuroscience research communications, 13, 1993, pp. 190000055-190000058
Citations number
20
Categorie Soggetti
Neurosciences
Journal title
Neuroscience research communications → ACNP
ISSN journal
08936609
Volume
13
Year of publication
1993
Supplement
1
Pages
190000055 - 190000058
Database
ISI
SICI code
0893-6609(1993)13:<190000055:TGP(ID>2.0.ZU;2-G
Abstract
The expression of the growth associated protein B-50 (GAP-43) is devel opmentally regulated and reinduced following neuronal injury. Using B- 50 as marker for sprouting in single and double immunolabeling of neoc ortex of Alzheimer's disease (AD) we demonstrate that bulbous B-50 imm unoreactive dystrophic neurites are found in beta-amyloid/A4 positive plaques. Our results and those of others indicate that dystrophic neur ites contain B-50 implicating this protein in the disease induced resp onse.