PEUTZ-JEGHERS SYNDROME WITH MALIGNIZATION OF A HAMARTOMATOUS POLYP

Peutz-Jeghers syndrome is characterized by hamartomatous polyps in the gastrointestinal tract associated with mucocutaneous melanin spots; t he condition is inherited in an autosomic dominant fashion. Although t he hamartomatous polyps are not regarded as malignant, there is an ass ociation between the Peutz-Jeghers syndrome and the development of car cinomas of the gastrointestinal tract. Similary, there is an increasin g evidence suggesting that hamartomas can give rise to adenocarcinomas . We present a patient with Peutz-Jeghers syndrome who developed an ad enocarcinoma in an hamartomatous jejunal polyp.