RETROVIRUS VARIATION AND REVERSE TRANSCRIPTION - ABNORMAL STRAND TRANSFERS RESULT IN RETROVIRUS GENETIC-VARIATION

Authors
TEMIN HM
Citation
Hm. Temin, RETROVIRUS VARIATION AND REVERSE TRANSCRIPTION - ABNORMAL STRAND TRANSFERS RESULT IN RETROVIRUS GENETIC-VARIATION, Proceedings of the National Academy of Sciences of the United Statesof America, 90(15), 1993, pp. 6900-6903
Citations number
44
Categorie Soggetti
Multidisciplinary Sciences
Journal title
Proceedings of the National Academy of Sciences of the United Statesof America → ACNP
ISSN journal
00278424
Volume
90
Issue
15
Year of publication
1993
Pages
6900 - 6903
Database
ISI
SICI code
0027-8424(1993)90:15<6900:RVART->2.0.ZU;2-J
Abstract
Human immunodeficiency virus variation is extensive and is based on nu merous mistakes in reverse transcription. All retrovirus replication r equires two strand transfers (growing point jumps) to synthesize the c omplete provirus. I propose that the numerous mistakes in reverse tran scription are the result of this requirement for the two strand transf ers needed to form the provirus.