DIVERSOMERS - AN APPROACH TO NONPEPTIDE, NONOLIGOMERIC CHEMICAL DIVERSITY

Authors
DEWITT SH KIELY JS STANKOVIC CJ SCHROEDER MC CODY DMR PAVIA MR
Citation
Sh. Dewitt et al., DIVERSOMERS - AN APPROACH TO NONPEPTIDE, NONOLIGOMERIC CHEMICAL DIVERSITY, Proceedings of the National Academy of Sciences of the United Statesof America, 90(15), 1993, pp. 6909-6913
Citations number
32
Categorie Soggetti
Multidisciplinary Sciences
Journal title
Proceedings of the National Academy of Sciences of the United Statesof America → ACNP
ISSN journal
00278424
Volume
90
Issue
15
Year of publication
1993
Pages
6909 - 6913
Database
ISI
SICI code
0027-8424(1993)90:15<6909:D-AATN>2.0.ZU;2-P
Abstract
Solid-phase chemistry, organic synthesis, and an apparatus for multipl e, simultaneous synthesis have been combined to generate libraries of organic compounds (''diversomers''). Arrays of compounds were synthesi zed over two to three steps incorporating chemically diverse building blocks on a polystyrene-based solid support in a multiple, simultaneou s manner. The generality of this approach is illustrated by the synthe ses of dipeptides, hydantoins, and benzodiazepines.