REGIONAL CEREBRAL GLUCOSE-METABOLISM IN LATE-LIFE DEPRESSION AND ALZHEIMER-DISEASE - A PRELIMINARY POSITRON EMISSION TOMOGRAPHY STUDY

Citation
A. Kumar et al., REGIONAL CEREBRAL GLUCOSE-METABOLISM IN LATE-LIFE DEPRESSION AND ALZHEIMER-DISEASE - A PRELIMINARY POSITRON EMISSION TOMOGRAPHY STUDY, Proceedings of the National Academy of Sciences of the United Statesof America, 90(15), 1993, pp. 7019-7023
Citations number
52
Categorie Soggetti
Multidisciplinary Sciences
ISSN journal
00278424
Volume
90
Issue
15
Year of publication
1993
Pages
7019 - 7023
Database
ISI
SICI code
0027-8424(1993)90:15<7019:RCGILD>2.0.ZU;2-K
Abstract
Eight subjects with late-life depression, eight subjects with probable Alzheimer disease, and eight healthy age-matched controls were studie d using 2-F-18!fluoro-2-deoxy-D-glucose positron emission tomography in the resting state with their eyes open and ears unoccluded. The dep ressed subjects showed widespread reductions in the regional cerebral metabolic rate for glucose in most major neocortical, subcortical, and paralimbic regions that were significantly different from control val ues (P < 0.01). The metabolic decrements in the depressed group were c omparable in magnitude to those seen in the Alzheimer disease group. T hese data demonstrate widespread nonfocal decline in glucose metabolis m in late-life depression that is comparable to the hypometabolism see n in Alzheimer disease. These findings have pathophysiological implica tions in major depressive disorder in the elderly.