SYNTHESIS OF THE SEROTONIN LIGANDS, RS-56532-C-14 AND RS-66331-C-14 FROM A COMMON LABELED INTERMEDIATE

Citation
Mr. Masjedizadeh et H. Parnes, SYNTHESIS OF THE SEROTONIN LIGANDS, RS-56532-C-14 AND RS-66331-C-14 FROM A COMMON LABELED INTERMEDIATE, Journal of labelled compounds & radiopharmaceuticals, 33(8), 1993, pp. 687-696
Citations number
14
Categorie Soggetti
Chemistry Analytical","Pharmacology & Pharmacy
ISSN journal
03624803
Volume
33
Issue
8
Year of publication
1993
Pages
687 - 696
Database
ISI
SICI code
0362-4803(1993)33:8<687:SOTSLR>2.0.ZU;2-A
Abstract
Two approaches towards the synthesis of 3-chloro-4-amino-1,8-naphthali c anhydride-C-14!, which served as the common intermediate in the pre paration of the two title compounds, are described. Although nucleophi lic incorporation of the label via KCN was superior to an electrophili c sequence using CO2, the latter approach was adopted since the nitril e could not be hydrolyzed to the desired acid. The specific activities of RS-56532-C-14 and RS-66331-C-14 were 56.8 mCi/mmol and 53.7 mCi/mm ol, respectively.