THE SYNTHESIS AND RESOLUTION OF TRITIATED 4-AMINO-3-PHENYLBUTANOIC ACID (H-3!R-BETA-PHENYLGABA) AND H-3! S-BETA-PHENYLGABA)

Authors
DUKE RK ALLAN RD DREW CA JOHNSTON GAR MEWETT KN LONG MA THAN C
Citation
Rk. Duke et al., THE SYNTHESIS AND RESOLUTION OF TRITIATED 4-AMINO-3-PHENYLBUTANOIC ACID (H-3!R-BETA-PHENYLGABA) AND H-3! S-BETA-PHENYLGABA), Journal of labelled compounds & radiopharmaceuticals, 33(8), 1993, pp. 767-775
Citations number
17
Categorie Soggetti
Chemistry Analytical","Pharmacology & Pharmacy
Journal title
Journal of labelled compounds & radiopharmaceuticals → ACNP
ISSN journal
03624803
Volume
33
Issue
8
Year of publication
1993
Pages
767 - 775
Database
ISI
SICI code
0362-4803(1993)33:8<767:TSAROT>2.0.ZU;2-F
Abstract
A synthesis of H-3!R- and H-3!S-4-amino-3-phenylbutanoic acid (H-3! R- and H-3!S-beta-phenylGABA) from the unsaturated intermediate by ca talytic hydrogenation using tritium gas in the presence of palladium o n charcoal is reported. The H-3!R- and H-3!S-diastereoisomers of pan tolactone ester of beta-phenylGABA were separated by HPLC.