IN-VIVO EFFECTS OF RUFLOXACIN AND CIPROFLOXACIN ON T-CELL SUBSETS ANDTUMOR-NECROSIS-FACTOR PRODUCTION IN MICE INFECTED WITH BACTEROIDES-FRAGILIS

Authors
GOLLAPUDI SV CHUAH SK HARVEY T THADEPALLI HD THADEPALLI H
Citation
Sv. Gollapudi et al., IN-VIVO EFFECTS OF RUFLOXACIN AND CIPROFLOXACIN ON T-CELL SUBSETS ANDTUMOR-NECROSIS-FACTOR PRODUCTION IN MICE INFECTED WITH BACTEROIDES-FRAGILIS, Antimicrobial agents and chemotherapy, 37(8), 1993, pp. 1711-1712
Citations number
14
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
37
Issue
8
Year of publication
1993
Pages
1711 - 1712
Database
ISI
SICI code
0066-4804(1993)37:8<1711:IEORAC>2.0.ZU;2-H
Abstract
We investigated the in vivo effects of rufloxacin and ciprofloxacin on T-cell subsets and tumor necrosis factor production in mice infected with Bacteroides fragilis. These quinolones did not alter the helper/s uppressor ratio but did modulate the kinetics of tumor necrosis factor production in infected animals. This result correlated with the obser ved therapeutic efficacies of the quinolones.