THE 5'-TRIPHOSPHATES OF THE (-) AND 1-2-(HYDROXYMETHYL)-1,3-OXATHIOLANE-5-YL!CYTOSINE EQUALLY INHIBIT HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 REVERSE-TRANSCRIPTASE() ENANTIOMERS OF CIS)

Authors
WILSON JE MARTIN JL BORROTOESODA K HOPKINS S PAINTER G LIOTTA DC FURMAN PA
Citation
Je. Wilson et al., THE 5'-TRIPHOSPHATES OF THE (-) AND 1-2-(HYDROXYMETHYL)-1,3-OXATHIOLANE-5-YL!CYTOSINE EQUALLY INHIBIT HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 REVERSE-TRANSCRIPTASE() ENANTIOMERS OF CIS), Antimicrobial agents and chemotherapy, 37(8), 1993, pp. 1720-1722
Citations number
14
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
37
Issue
8
Year of publication
1993
Pages
1720 - 1722
Database
ISI
SICI code
0066-4804(1993)37:8<1720:T5OT(A>2.0.ZU;2-5
Abstract
The (-) enantiomer of 1-2-(hydroxymethyl)-1,3-oxathiolane-5-yl!cytosi ne is a potent inhibitor of human immunodeficiency virus type 1 in vit ro. The 5'-triphosphates of the (-) and (+) enantiomers equally inhibi ted the production of full-length minus-strand DNA in an endogenous re verse transcriptase reaction, each competitively inhibited DNA synthes is, and each was used as a chain-terminating substrate.