FATIGUE, SLEEP DISTURBANCES AND CIRCADIAN-RHYTHM IN MULTIPLE-SCLEROSIS

The aim of this study was to investigate whether fatigue and sleep dis turbances in multiple sclerosis (MS) patients might be due to disrupte d circadian sleep wake regulation. Actigraphy and a multiple sleep lat ency test (MSLT) were performed in 16 MS patients with both prominent sleep complaints and fatigue. Actigraphy scores did not differ from co ntrol values, whereas sleep onset latency values were altered in subgr oups of MS patients. No evidence was found for a generalized circadian disturbance in MS patients.