Ch. Gonzalez et al., LIMB DEFICIENCY WITH OR WITHOUT MOBIUS SEQUENCE IN 7 BRAZILIAN CHILDREN ASSOCIATED WITH MISOPROSTOL USE IN THE 1ST TRIMESTER OF PREGNANCY, American journal of medical genetics, 47(1), 1993, pp. 59-64
Misoprostol, a synthetic analog of prostaglandin, has been widely used
in Brazil as an abortifacient. Abortion is illegal in Brazil. An unce
rtain number of these abortion attempts are unsuccessful and the pregn
ancy continues. We report on 7 patients whose mothers attempted to abo
rt using this drug in the first trimester of gestation without success
. The 7 patients presented with limb defects and in 4 of them a diagno
sis of Mobius sequence was made. (C) 1993 Wiley-Liss, Inc.