ACUTE HEMODYNAMIC-EFFECTS OF BUNAZOSIN IN CONGESTIVE-HEART-FAILURE DIFFERING RESPONSES ACCORDING TO DEGREE OF CARDIAC DYSFUNCTION

1. Hemodynamic responses to Bunazosin (BZN) in congestive heart failur e (CHF) were evaluated for 6 hours (hr) in 30 patients (A, normal card iac function; B, mild cardiac dysfunction; C, severe cardiac dysfuncti on). 2. For 6 hr after BZN, the increments of cardiac index (DELTA CI) and stroke volume index (DELTA SVI) with BZN were higher in groups A and B than in group C. 3. A significant positive correlation was obser ved between ejection fraction and maximum DELTA CI and SVI, and betwee n % fractional shortening and maximum DELTA CI and SVI. 4. These data showed that BZN improved the hemodynamics of CHF patients and that pat ients in groups A and B responded well to this vasodilator, however, p atients in group C did not. 6025