MULTIPLE-SCLEROSIS WITH BILATERAL CONTINUOUS CYSTIC LESIONS ALONG LATERAL VENTRICLES AND CAUDATE-CALLOSAL ANGLES (WETTERWINKEL)

We report a 53-year-old female autopsy case of multiple sclerosis with bilateral continuous cystic lesions along the lateral ventricles and caudate-callosal angles (Wetterwinkel). The pathophysiological mechani sms underlying these peculiar huge cystic lesions can be explained by the appearance of necrotic tissue during the recurrent relapsing stage s of the disease, and then, by the absorption and scavenging of activa ted microglias. Poor astocytic gliosis, which might be an effect of fr equent use of corticosteroids during the clinical course makes the cav ities bigger.