Based on our experience with valproate during presurgical workup and e
pilepsy surgery, we recommend routine prothrombin and partial thrombop
lastin times and platelet count in all patients on valproate prior to
the insertion of sphenoidal leads. We also recommend routine discontin
uation of valproate at least 2 weeks prior to epilepsy surgery. In add
ition, we prohibit its use in the immediate postoperative period.