EXPERIMENTAL AND CLINICAL INVESTIGATIONS ON THE BIOLOGY OF BLADDER-CARCINOMA

Knowledge of the natural development of a bladder carcinoma is of impo rtance for its treatment. The natural course of bladder cancer disease is seldom known in humans, as only the treated natural history is sub ject to investigation. As a result of the long latency period (1 - 5 4 years) between carcinogenic exposure and cancer development, only a l imited number of clinical observations on human bladder carcinogenesis exist (Gross 1967, Koss et al. 1964). Cancer research in animals and the development of experimental set-ups are necessary to develop model s that facilitate the diagnosis and choice of therapeutic approach in human bladder cancer disease. We present our experimental and clinical data concerning bladder cancer.