3 SICKLE-CELL-ANEMIA PATIENTS EACH WITH A DIFFERENT ALPHA-CHAIN VARIANT - DIAGNOSTIC COMPLICATIONS

Authors
GU LH WILSON JB MOLCHANOVA TP MCKIE KM MCKIE VC HUISMAN THJ
Citation
Lh. Gu et al., 3 SICKLE-CELL-ANEMIA PATIENTS EACH WITH A DIFFERENT ALPHA-CHAIN VARIANT - DIAGNOSTIC COMPLICATIONS, Hemoglobin, 17(4), 1993, pp. 295-301
Citations number
14
Categorie Soggetti
Biology,Hematology
Journal title
Hemoglobin → ACNP
ISSN journal
03630269
Volume
17
Issue
4
Year of publication
1993
Pages
295 - 301
Database
ISI
SICI code
0363-0269(1993)17:4<295:3SPEWA>2.0.ZU;2-Z
Abstract
We have studied three sickle cell anemia patients who also carried a h eterozygosity for one of the following alpha chain abnormalities: Hb G -Philadelphia alpha 68(E17)Asn-->Lys!, Hb Montgomery alpha 48 (CE6)L eu-->Arg!, and Hb Chicago alpha 136(H19)Leu-->Met!. Electrophoretic a nalyses alone may result in incomplete and incorrect information. Conf irmation of the diagnosis of Hb SS or Hb SC disease by one of the fast high performance liquid chromatographic procedures is recommended.