DETERMINATION OF FORMULATION QUANTITIES F OR 3 KINDS OF ANTACID USINGTRIANGLE COORDINATES

We investigate the method for the determination of an appropriate mixi ng region of three kinds of antacid, magnesium hydroxide, dried alumin um hydroxide gel and calcium carbonate using trianglular coordinates. Using the trianglular coordinates, the appropriate mixing region of sa tisfying the following categories was determined; 1) acid neutralizing capacity (200 ml), 2) immediate action (pH 6--8 range obtained 10 min after pouring an antacid into 50 ml of 0.1 mol/l HCl (aq) sol.), 3) b owel property (mel ratio of Mg/Al = 1--3), and 4) quantities of combin ation of three antacids (under 700 mg of total quantities). Modified F uchs Test was performed at some points which met the above conditions. The durability of the combination of these three antacids was evaluat ed. The following regions have long durability of antacids (about 60 m in for persisting pH 3.5--5); magnesium hydroxide 40--60%, dried alumi num hydroxide gel 3--50% and calcium carbonate 10%. In the cases of ch anging the above mentioned conditions, and of using different kinds of antacid, the determination of the appropriate mixing region using tri angular coordinates is effective for the pharmaceutical technology. In this study we emphasize the following striking features; utilization of triangular coordinates, fixing the combination of antacid, and inco rporation of three kinds of antacid with aluminum, magnesium and calci um.