A previously reported unicystic ameloblastoma, showing luminal plexifo
rm epithelial proliferation and the presence of small islands of odont
ogenic epithelium in the connective tissue of the cyst wall, recurred
5 years after conservative surgery. The tumour was nucleated and since
the epithelial islands were confined to its fibrous capsule a conserv
ative approach was regarded as adequate. In view of the later experien
ce it is now proposed that where cystic ameloblastomas depict epitheli
al infiltration into the capsule a second excision be considered and t
hat such surgical material be thoroughly examined for signs of epithel
ial infiltration. Whatever type of treatment the surgeon decides to pe
rform, it is essential to have a long postoperative period of monitori
ng. Because the presence of islands of odontogenic epithelium in the c
yst wall influences the surgical approach, it is recommended that path
ologists carefully examine cystic ameloblastoma surgical specimens for
their presence. Multiple, even serial sections are required for such
examinations. The pathology report should include a description of the
islands with an indication of their site in the capsule of the tumour
.