A cross-sectional survey design investigated the relationship of schoo
l and home self-esteem to history of substance use, membership in alte
rnative education (non-mainstream) school programs, gender, and race.
Self-esteem was assessed using the Hare Self-Esteem Scale. Four hundre
d eleven sixth grade students completed the survey. Results revealed h
ome self-esteem related inversely to tobacco use (F = 15.39, df = 2,34
3, p < .0001), alcohol use (F = 12.08, df = 2,343, p < .0001), and use
of other drugs (F = 12.28, df = 2,338, p < .0001). Similarly school s
elf-esteem related inversely to tobacco use (F = 15.47, df = 2,354, p
< .0001), alcohol use (F = 8.74, df = 2,353, p = .0002), and use of ot
her drugs (F = 9.30, df = 2,350, p < .0001). Regardless of type of dru
g, recent users had the lowest self-esteem scores on both subscales an
d never users had the highest scores. Subjects enrolled in non-mainstr
eam programs had significantly lower home and school self-esteem score
s than did subjects in mainstream classes. Race and gender were not as
sociated significantly with self-esteem. Implications for youth substa
nce use prevention and research are discussed.