Amidst confusion about the nature and usefulness of the stress constru
ct and distinctions between acute and chronic stress, research has beg
un to identify mechanisms by which stress affects health and by which
stress can persist beyond the physical presence of the stressor. In ad
dition, research has begun to identify reasons for selective vulnerabi
lity to chronic stress. One of the possible reasons for chronic stress
following traumatic events is the disorganizing effect of loss of con
trol and violation of expectations for regulating aspects of one's lif
e normally under control. Data from a longitudinal study of chronic st
ress at Three Mile Island in the wake of the nuclear accident there su
ggest that loss of control and frequent experience of intrusive memori
es about the accident and its aftermath were related to persistent str
ess responding several years after the accident. The relationships bet
ween stress responding and conditioning and consolidation of stressful
memories are considered as a basis for persistent intrusive memories
and chronic stress.