RENAL RESPONSES TO MAGNESIUM LITHOSPERMATE-B IN RATS WITH ADENINE-INDUCED RENAL-FAILURE

A study was conducted to investigate the effects of magnesium lithospe rmate B on the uraemic symptoms and development of hypertension in rat s with adenine-induced renal failure. Chronic administration of 10 mg/ kg body weight/day magnesium lithospermate B significantly reduced ser um urea nitrogen, creatinine, methylguanidine, guanidinosuccinic acid and inorganic phosphate, accompanied by increased urinary excretion of urea, creatinine and electrolytes. In addition, renal tissue blood fl ow was significantly increased and mean blood pressure significantly d ecreased in the magnesium lithospermate B-treated group compared with the control group. These results confirm that chronic administration o f magnesium lithospermate B to rats with adenine-induced renal failure ameliorates the uraemic symptoms and development of hypertension by i mproving renal haemodynamics and electrolyte metabolism.