BEHAVIOR OF OXYGEN EFFECT UNDER CONDITION S OF NORMOBARIC HYPOXIC HYPOXIA IN THE INTRAUTERINE AND POSTNATAL DEVELOPMENTAL PERIODS

The experiments on rats have shown that hypoxic ps mixture,containing 10 % of oxygen and 90 % of nitrogen (HGM-10) under normobaric conditio ns exerts a highly reliable radioprotective effect on progeny when 11- day pregnant animals are exposed to total irradiation (Co-60, 20 Gy). As distinct from the known radioprotector, mexamine, (5-methoxytryptam ine), HGM-10 has a pronounced radioprotective effect during the first days (1-5) after birth. Radioresistance of new-born rats correlates wi th the level of pO2 in the tissues which progressively decreases with respiration of HGM-10 and remains unchanged after mexamine (10 mg/kg) introduction.