It is important to know the status of internal mammary lymph node (IMN
) in estimating the prognosis in patients with breast cancer and/or pl
anning the treatment. In the first series of this study, the diagnosti
c value of internal mammary lymphoscintigraphy (IMLS) and that of para
sternal sonography (PS) were evaluated in 57 patients. The overall dia
gnostic accuracy of IMLS was 72% and that of PS, 84%, compared with IM
N metastases confirmed on a biopsy. In the second series, 23 patients
who underwent extended radical mastectomy and were found to have IMN m
etastases, were examined for the sizes and locations of metastatic IMN
. Minute metastatic lymph nodes not detectable by IMLS or PS were foun
d in 9 (39%) of the patients. However, the incidence of metastases to
the first and/or second intercostal spaces was 97% for the patients. W
e concluded that a biopsy of the first and second intercostal spaces i
s useful in providing the information of IMN status.