CURRENT APPROACHES TO THE PREVENTION OF I NFECTIOUS COMPLICATIONS IN CARDIOSURGERY

Due to changes of humoral immunity, patients with rheumatic heart dise ase present, even before the operation, a high-risk group with regard to the development of infectious complications. Contamination of intra operative material was revealed in 61.7 % of cases duerin the operatio n. Extracorporeal circulation increases the cefotaxime half-life perio d which is in direct proportional dependence on the period of time bet ween the beginning of the administration of the agent and the beginnin g of extracorporeal circulation. Immunocorrection by means of myelopid in the early postoperative period accelerates restoration of cellular and humoral immunity, and reduces the frequency of pneumonia occurren ce and suppuration of the postoperative wound. Therefore, the preventi on of infectious complications after operations on an open heart shoul d be complex and should include broad-spectrum antibiotics and immunoc orrective therapy.