IMIPRAMINE TREATMENT OF ALCOHOLISM WITH COMORBID DEPRESSION

Authors
NUNES EV MCGRATH PJ QUITKIN FM STEWART JP HARRISON W TRICAMO E OCEPEKWELIKSON K
Citation
Ev. Nunes et al., IMIPRAMINE TREATMENT OF ALCOHOLISM WITH COMORBID DEPRESSION, The American journal of psychiatry, 150(6), 1993, pp. 963-965
Citations number
10
Categorie Soggetti
Psychiatry,Psychiatry
Journal title
The American journal of psychiatry → ACNP
ISSN journal
0002953X
Volume
150
Issue
6
Year of publication
1993
Pages
963 - 965
Database
ISI
SICI code
0002-953X(1993)150:6<963:ITOAWC>2.0.ZU;2-P
Abstract
Of 60 depressed alcoholics who completed an open trial of imipramine, 27 (45%) responded with improvement in both mood and drinking behavior , and eight (13%) responded after further dosage increases or treatmen t with disulfiram. In a subsequent 6-month, randomized discontinuation trial, four of 13 subjects (31%) relapsed during imipramine treatment and seven of 10 (70%) relapsed while taking placebo. This suggests a potential treatment approach for a risk subgroup of alcoholics.