EPIDEMIOLOGY OF HEPATOCELLULAR-CARCINOMA IN A PROVINCE OF NORTHERN ITALY - PREVALENCE OF THE RISK-FACTORS AND INCIDENCE IN THE POPULATION

Epidemiologic studies on hepatocellular carcinoma (HCC) in limited geo graphic areas of Italy are rare, and most of them derive from autopsie s. We retrospectively analyzed the prevalence of risk factors (sex, ag e, HBsAg, alcoholism, cirrhosis) in 137 HCC diagnosed between 1980 and 1989 in a single centre of northern Italy (Bergamo). Results and conc lusions: One hundred and nine of the HCC (79.6 %) occurred in men (M:F = 3.9:1); 35.8 % were HBsAg + and 41.4 % had histories of alcoholism. There were significant differences between men and women as regards p revalence of HBsAg+ (40.4 % vs 17.9 %; p = 0.046) and alcoholism (47.6 % vs 17.9 %, p = 0.008). The mean age of the patients was 63.6 years (range, 40-82), with significant differences between men and women (62 .4 +/- 08 vs 68.2 +/- 1.4, p = 0.001), between HCC/HBsAg+ and HCC/HBsA g- (59.1 +/- 1.1 vs 66.1 +/- 0.8, p = 0.00001) and between alcoholics and nonalcoholics (61.6 +/- 1.1 vs 64.8 +/- 0.9; p = 0.03). Liver cirr hosis was associated with HCC in 104/122 cases (data not available for 15 patients) without differences in distribution of sex, age, HBsAgor alcoholism between HCC with cirrhosis and HCC without cirrhosis. In cidence was calculated for the surrounding territory of the hospital c enter (10 towns, districts 5 and 6, USSL 30). Fifty-four cases of HCC were found in this area over the 10-year period, in according with a m ean standardized incidence rate (Lombardy population 1971) of 11.7/100 ,000 inhabitants/year (c.i. 95 %, 1.49-21.86).