PROTECTION AGAINST LETHAL TOXICITY OF VARIOUS ANTICANCER DRUGS BY PREINDUCTION OF METALLOTHIONEIN SYNTHESIS IN MICE

Authors
SATOH M TSUCHIYA T KUMADA Y NAGANUMA A IMURA N
Citation
M. Satoh et al., PROTECTION AGAINST LETHAL TOXICITY OF VARIOUS ANTICANCER DRUGS BY PREINDUCTION OF METALLOTHIONEIN SYNTHESIS IN MICE, The Journal of trace elements in experimental medicine, 6(1), 1993, pp. 41-44
Citations number
10
Categorie Soggetti
Biology
Journal title
The Journal of trace elements in experimental medicine → ACNP
ISSN journal
0896548X
Volume
6
Issue
1
Year of publication
1993
Pages
41 - 44
Database
ISI
SICI code
0896-548X(1993)6:1<41:PALTOV>2.0.ZU;2-I
Abstract
The effect of pretreatment with metallothionein (MT) inducing metal co mpounds (bismuth subnitrate (BSN) or ZnCl2) on survival rates of mice receiving various anticancer drugs was investigated. The survival rate s of BSN-pretreated mice were 100, 63, 43, and 100% in cis-diamminedic hloroplatinum, adriamycin, peplomycin, and 5-fluorouracil treated grou ps, respectively, although mice given an anticancer drug alone died wi thin 13 days. Moreover, pretreatment with ZnCl2 remarkably reduced let hality of cyclophosphamide in addition to that of the other drugs desc ribed above. These results suggest that MT inducing agents may be effe ctive as protective agents against certain side effects of various ant icancer drugs.