SPECTRUM OF PRIMARY CUTANEOUS CD30 (KI-1)-POSITIVE LYMPHOPROLIFERATIVE DISORDERS - A PROPOSAL FOR CLASSIFICATION AND GUIDELINES FOR MANAGEMENT AND TREATMENT

Primary cutaneous CD30 (Ki-1)-positive, large cell lymphomas (LCLs) re present a recently recognized group of cutaneous T-cell lymphomas with a favorable prognosis. The characteristic features of this cutaneous lymphoma are reviewed, differences with primary noncutaneous CD30+ LCL s emphasized, and its relation with other CD30+ cutaneous lymphoprolif erative disorders, in particular lymphomatoid papulosis, is discussed. These primary cutaneous CD30+ LCLs, lymphomatoid papulosis, and relat ed conditions represent a clinical and histologic continuum. A classif ication with practical guidelines for the management and treatment of patients within this spectrum of lymphoproliferative disorders is pres ented.