Ja. Santiago et al., INHIBITORY EFFECTS OF HOE-140 ON VASODILATOR RESPONSES TO BRADYKININ IN THE MESENTERIC VASCULAR BED OF THE CAT, European journal of pharmacology, 236(2), 1993, pp. 315-318
The effect of Hoe 140, a bradykinin B2 receptor antagonist, on vasodil
ator responses to bradykinin was investigated in the mesenteric vascul
ar bed of the cat under constant flow conditions. Injections of bradyk
inin into the mesenteric vascular bed induced dose-related decreases i
n perfusion pressure which were reduced significantly following admini
stration of Hoe 140 (D-Arg-[Hyp3,Thi5,D-Tic7,Oic8]bradykinin) (100 mug
/kg i.v.). The inhibitory effects of Hoe 140 were longer than 3 h in d
uration and vasodilator responses to acetylcholine and S-nitroso-N-ace
tylpenicillamine and vasoconstrictor responses to norepinephrine, angi
otensin II, and the thromboxane mimic, U46619 -dideoxy-11alpha,9alpha-
epoxymethano-prostaglandin F2alpha) were unchanged by the B2 receptor
antagonist. Hoe 140 had little effect on baseline systemic arterial an
d mesenteric arterial perfusion pressures. These results suggest that
Hoe 140 is a potent, highly selective, long-acting bradykinin B2 recep
tor antagonist with little agonistic activity in the mesenteric vascul
ar bed of the cat.