DUP-753 PREVENTS THE DEVELOPMENT OF PUROMYCIN AMINONUCLEOSIDE-INDUCEDNEPHROSIS

Authors
YAYAMA K KAWAO M TUJII H ITOH N OKAMOTO H
Citation
K. Yayama et al., DUP-753 PREVENTS THE DEVELOPMENT OF PUROMYCIN AMINONUCLEOSIDE-INDUCEDNEPHROSIS, European journal of pharmacology, 236(2), 1993, pp. 337-338
Citations number
7
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
European journal of pharmacology → ACNP
ISSN journal
00142999
Volume
236
Issue
2
Year of publication
1993
Pages
337 - 338
Database
ISI
SICI code
0014-2999(1993)236:2<337:DPTDOP>2.0.ZU;2-U
Abstract
The appearance of nephrotic syndromes such as proteinuria, hypoalbumin emia, hypercholesterolemia and increase in blood nitrogen urea, induce d in rats by injection of puromycin aminonucleoside was markedly inhib ited by oral administration of Dup 753 (losartan), a novel angiotensin II receptor antagonist, at a dose of 1 or 2 mg/kg per day. The result s suggest a possible involvement of the renin-angiotensin system in th e development of puromycin aminonucleoside-induced nephrosis.