AGE-DEPENDENT DIFFERENT CONSEQUENCES OF BILATERAL-NEPHRECTOMY (NX) INRATS

Adult rats survived the removal of both kidneys (NX) for about 48 hour s; survival time was distinctly lower in 10- and 20-day-old rats (abou t 24 hrs). Some of the measured parameters indicate age dependent diff erences in uremic impairment. In the prefinal period after NX blood ur ea nitrogen concentrations were distinctly higher in adult than in you ng rats. After nephrectomy diminution of the concentrations of GSH and GSSG in liver tissue is more distinct in adult than in young rats. Si milarly, 24 hrs after NX the content of lipid peroxides in liver tissu e was higher in adult than in 10- and 20-day-old rats. Furthermore, th e prolongation of bleeding time in uremic rats was more distinct in ad ult than in young rats. The following parameters indicate uremic impai rment clearly, but age dependent differences do not exist: Increase of potassium concentration in plasma, enhanced activities of liver speci fic enzymes in plasma, reduced concentration of various amino acids in plasma and distinct increase in plasma concentration of taurine.