Gj. Amabeoku et al., PHARMACOKINETIC INTERACTION OF SINGLE DOSES OF QUININE AND CARBAMAZEPINE, PHENOBARBITONE AND PHENYTOIN IN HEALTHY-VOLUNTEERS, East African medical journal, 70(2), 1993, pp. 90-93
Effects of single doses of quinine on plasma and urine concentrations
of carbamazepine, phenobarbitone and phenytoin were studied in healthy
volunteers. Quinine (600mg, p.o.) markedly augmented the peak plasma
concentrations and area under the curve (AUC [0-24]) values of carbama
zepine (200mg, p.o.) and phenobarbitone (120mg, p.o.) but did not affe
ct those of phenytoin (200mg, p.o.). Mean urinary recoveries of carbam
azepine, phenobarbitone and phenytoin over 24 hours also profoundly in
creased with concomitant administration of quinine. These results indi
cate possible interaction between quinine and carbamazepine or phenoba
rbitone.