REACTION OF SALIGENIN CYCLIC PHOSPHORUS ESTERS WITH SOME AMINO-ACIDS AND PURINE AND PYRIMIDINE-BASES

2-Phenoxy-4H-1,3,2-benzodioxaphosphorin 2-oxide (K-2), a kind of salig enin cyclic phosphorus esters, reacts with some nucleophiles to form t he 2-hydoxybenzyl derivatives. The reactivity of K-2 with some biologi cally important components of organisms, such as amino acids, purine b ases and pyrimidine bases, were investigated. Under neutral conditions , the reactivity of K-2 with them was not observable. Although serine and tyrosine did not react with K-2 under alkaline conditions, cystein e, histidine and arginine did and gave the corresponding 2-hydroxybenz yl derivatives. With purine and pyrimidine bases, no observable reacti on occurred under any employed conditions.