4,4'-DI-TERT-BUTYLBIPHENYL-CATALYZED LITHIATION OF CHLOROMETHYL ETHYLETHER - A BARBIER-TYPE NEW AND EASY ALTERNATIVE TO ETHYL LITHIOMETHYLETHER

Authors
GUIJARRO A YUS M
Citation
A. Guijarro et M. Yus, 4,4'-DI-TERT-BUTYLBIPHENYL-CATALYZED LITHIATION OF CHLOROMETHYL ETHYLETHER - A BARBIER-TYPE NEW AND EASY ALTERNATIVE TO ETHYL LITHIOMETHYLETHER, Tetrahedron letters, 34(21), 1993, pp. 3487-3490
Citations number
41
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
34
Issue
21
Year of publication
1993
Pages
3487 - 3490
Database
ISI
SICI code
0040-4039(1993)34:21<3487:4LOCE>2.0.ZU;2-9
Abstract
The reaction of an equimolar amount of chloromethyl ethyl ether (1) an d different carbonyl compounds (2) with an excess of lithium powder (1 :7 molar ratio) in the presence of a catalytic amount of 4,4'-di-tert- butylbiphenyl (5 mol %) in THF at 0-degrees-C leads, after hydrolysis, to the corresponding hydroxyethers 3.