DETERMINATION OF SUPEROXIDE DISMUTASE-LIKE ACTIVITY OF COPPER(II) COMPLEXES - RELEVANCE OF THE SPECIATION FOR THE CORRECT INTERPRETATION OFINVITRO O2- SCAVENGER ACTIVITY

Authors
COSTANZO LL DEGUIDI G GIUFFRIDA S RIZZARELLI E VECCHIO G
Citation
Ll. Costanzo et al., DETERMINATION OF SUPEROXIDE DISMUTASE-LIKE ACTIVITY OF COPPER(II) COMPLEXES - RELEVANCE OF THE SPECIATION FOR THE CORRECT INTERPRETATION OFINVITRO O2- SCAVENGER ACTIVITY, Journal of inorganic biochemistry, 50(4), 1993, pp. 273-281
Citations number
53
Categorie Soggetti
Biology,"Chemistry Inorganic & Nuclear
Journal title
Journal of inorganic biochemistry → ACNP
ISSN journal
01620134
Volume
50
Issue
4
Year of publication
1993
Pages
273 - 281
Database
ISI
SICI code
0162-0134(1993)50:4<273:DOSDAO>2.0.ZU;2-7
Abstract
The superoxide dismutase activity of several copper(II) complexes of l inear and cyclic dipeptides has been measured. The results of a classi c indirect method (xanthine-xanthine oxidase) have been compared with those obtained by generation of the superoxide radical through 2-(-3-b enzoylphenyl)propionic acid (ketoprofen) photolysis. A simulation appr oach, based on the knowledge of the stability constants of the differe nt complex species existing in experimental conditions. has allowed us to obtain the correct speciation and to use these data to calculate t he pertinent catalytic constants.