Two new neo-clerodane diterpenoids, scutegalins A and B, have been iso
lated from the acetone extract of the aerial parts of Scutellaria gale
riculata, in addition to the known diterpenes jodrellin T and 14,15-di
hydrojodrellin T. The structures of the new diterpenoids were establis
hed by chemical and spectroscopic means, including an X-ray diffractio
n analysis of a derivative of scutegalin B. The antifeedant activity o
f scutegalins A and B and derivatives against Spodoptera littoralis ha
s been determined and structure-antifeedant activity relationships are
discussed.