Sk. Mishra et al., ATTEMPTED SYNTHESIS OF SUBSTITUTED 8-OXO-4-OXA-1-AZABICYCLO[3,3,0]OCTANE THROUGH INTRAMOLECULAR REDUCTIVE CYCLIZATION, Indian journal of chemistry. Sect. B: organic chemistry, including medical chemistry, 32(6), 1993, pp. 641-644
Reductive intramolecular cyclisation of 2-(N-succinimido)-1-ethanol gi
ves 8-oxo-4-oxa-1-aza-bicyclo[3,3,0]octane in a good yield. On introdu
ction of further substitution of C-1 and C-2 no cyclisation is observe
d. A mechanistic rational is presented.