Tuberculosis (TB) has reemerged as a major public health concern in th
e United States, with increasing impact upon women of childbearing and
childrearing age. As a primary health care provider, the certified nu
rse-midwife (CNM) must be able to respond to a variety of client conce
rns and questions. This article reviews the natural history and changi
ng epidemiology of TB. An in-depth focus on skin testing describes com
mon errors in administration and interpretation, and how to clearly ex
plain the meaning of a positive PPD result. Clinical presentations of
active TB are summarized, with their implications for pregnancy and fe
rtility. The final sections discuss the workup of latent TB to rule ou
t active disease and outline standards for management and therapy. Com
bining a sound knowledge base with expertise in client education and c
ounseling enables CNMs to make unique contributions to the broad effor
t to contain the new TB epidemic.