ENHANCED GASTRIC-MUCOSAL LEUKOTRIENE-B(4) SYNTHESIS IN PATIENTS TAKING NONSTEROIDAL ANTIINFLAMMATORY DRUGS

The effects of longstanding non-steroidal anti-inflammatory drug (NSAI D) treatment on gastric mucosal synthesis of leukotriene B4 (LTB4), le ukotriene C4 (LTC4), and prostaglandin E2 (PGE2) was studied. Gastric antral biopsies in 65 patients with arthritis taking NSAIDs and 23 con trol patients were taken and eicosanoid concentrations, stimulated by vortex mixing or calcium ionophore, were measured by radioimmunoassay. Median gastric mucosal synthesis of LTB4 was increased in patients ta king NSAIDs compared with non-users: (0.9 (0.2-2.5) pg/mg upsilon 0 (0 -0.6) pg/mg (p<0.001)). These differences persisted when subgroups of patients were analysed according to Helicobacter pylori colonisation o r degree of mucosal injury. Synthesis of LTB4 was strongly associated with the presence of type C (chemical) gastritis. Increased synthesis of LTC4 was associated with Helicobacter pylori colonisation but not N SAID use. Synthesis of PGE2 was decreased in patients taking NSAIDs co mpared with control patients (p<0.001). Enhanced gastric mucosal synth esis of LTB4 in patients taking NSAIDs may represent a primary effect of these drugs and could be implicated in the pathogenesis of gastriti s and ulceration associated with NSAIDs.