ADJUVANTED VACCINE AGAINST THE CAPRINE AR THRITIS-ENCEPHALITIS VIRUS .1. CLINICAL AND VIROLOGICAL STUDY

In purpose to protect goats against caprine arthritis encephalitis vir us (CAEV), the first group of kids (I) was inoculated with purified, i nactivated and adjuved virions, the second group (II) with adjuvant an d the third one (III) with culture medium. 2-4 months later, the three groups were challenged with virulent CAEV by intraarticular route. On the clinical level, vacccinated and challenged kids show more early a nd severe arthritis than other groups. On the virological level, isola tion of lentivirus from white blood cells and different organs is more important in group I than groups II and III. Therefore, vaccination w ith inactivated and adjuved virions do not protect against a virulent challenge; there is an enhancement of lesions. We note that the adjuva nt elicits a mild non-specific protection against virulent challenge.