PRODUCTION OF CHIRAL C3-UNITS BASED ON MI CROBIAL RESOLUTION AND THEIR SYNTHETIC APPLICATIONS

We developed to produce optically pure glycerol derivatives, such as ( R) and (S)-2,3-dichloro-1-propanols, and (R) and (S)-3-chloro-1,2-prop anediols, based on microbial resolution. These compounds are precursor s of optically active epichlorohydrins and glycidols which are used fo r wide variety of organic syntheses. We describe here the new methods to obtain these chiral C3 units and their several synthetic applicatio ns.