PRODUCTION OF INTERLEUKIN-6 BY HUMAN AND MURINE MONONUCLEAR LEUKOCYTES STIMULATED WITH PLASMODIUM ANTIGENS IS ENHANCED BY PENTOXIFYLLINE, AND TUMOR-NECROSIS-FACTOR SECRETION IS REDUCED

Authors
PRADA J PRAGER C NEIFER S BIENZLE U KREMSNER PG
Citation
J. Prada et al., PRODUCTION OF INTERLEUKIN-6 BY HUMAN AND MURINE MONONUCLEAR LEUKOCYTES STIMULATED WITH PLASMODIUM ANTIGENS IS ENHANCED BY PENTOXIFYLLINE, AND TUMOR-NECROSIS-FACTOR SECRETION IS REDUCED, Infection and immunity, 61(6), 1993, pp. 2737-2740
Citations number
29
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
Infection and immunity → ACNP
ISSN journal
00199567
Volume
61
Issue
6
Year of publication
1993
Pages
2737 - 2740
Database
ISI
SICI code
0019-9567(1993)61:6<2737:POIBHA>2.0.ZU;2-3
Abstract
When pentoxifylline was present during stimulation of human mononuclea r leukocytes with Plasmodium falciparum exogenous antigens, an increas e in interleukin-6 production was observed simultaneously with a reduc tion of tumor necrosis factor secretion. Similar results were obtained in murine macrophages stimulated with P. vinckei antigens. This indic ates the independence of interleukin-6 and tumor necrosis factor secre tion in response to malaria antigens.