WEAK RESISTANCE TO OXIDATION OF NATIVE LIPOPROTEINS IN WISTAR RATS

We report an impressive decline in plasma lipid resistance to oxidatio n during Triton-WR-1339-induced hyperlipidemia in rats. This decline i s associated with a modification in the balances between alpha-tocophe rol and lipids and alpha-tocopherol and ascorbate. These results are c onsistent with a weak resistance of accumulated native lipoproteins in plasma to oxidation, during a 6-hour time course, and they suggest a misunderstood role of lipoprotein catabolic enzymes: to improve this c haracteristic. Conclusively, the results lead us to propound Triton-in duced hyperlipidemia as an original model for studying the balance imp airment between antioxidants and oxidizable substrates.