SYNTHESIS OF LIPOXYGENASE INHIBITORS .1. SYNTHESIS OF OPEN AMIDRAZONES

Authors
NUHN P BUGE A HARENBERG P LETTAU H MOSCHNER K RAUCHMAUL M SCHNEIDER R
Citation
P. Nuhn et al., SYNTHESIS OF LIPOXYGENASE INHIBITORS .1. SYNTHESIS OF OPEN AMIDRAZONES, Die Pharmazie, 48(5), 1993, pp. 340-342
Citations number
19
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Die Pharmazie → ACNP
ISSN journal
00317144
Volume
48
Issue
5
Year of publication
1993
Pages
340 - 342
Database
ISI
SICI code
0031-7144(1993)48:5<340:SOLI.S>2.0.ZU;2-A
Abstract
The synthesis of some amidrazones as bioisosteric diazaallyl radicals is described starting from the reaction mechanism of the lipoxygenases which postulates the existence of a radical after hydrogen abstractio n from the arachidonic acid. N1,N3-diaryl-, N1-aryl-N3-alkyl-benzamidr azones and N1-arylacetamidrazones are strong inhibitors of the soja li poxygenase.