SYNTHESIS OF THIENO[2,3-B]PYRIDINES WITH AN OXALAMIDIC ACID OR AN OXALAMIDIC ALKYLESTER RESIDUE AND OF 4-ALKOXY-PYRIDO[3',2' 4,5]THIENO[3,2-D]PYRIMIDINE-2-CARBOXYLIC ACID-DERIVATIVES/

2-Alkoxycarbonyl-thieno[2,3-b]pyrid-3-yl)oxalamide acid alkylester B w ere synthesized by the reaction of 3-amino-2-carboxylic esters A with oxalic acid diethylester in presence of sodium alkoxides. The 3-amino- 2-cyano-thieno[2,3-b]pyridines C yielded under the same conditions via the N-(2-cyano-thieno[2,3-b]pyrid-3-yl)oxalamidic acid alkylesters D/ 1-D/4 the 4-alkoxy-pyrido[3',2': 4,5]thieno[3,2-d]pyrimidine-2-carboxy lic acid alkylesters E/1-E/8. The compounds D/1, D/2 and E/1-E/5 were hydrolyzed to give the corresponding carboxylic acids. The 3-amino-fur o[2,3-b]pyridine-2-carboxylic acid ethylester H reacted with oxalic et hylester chloride to give the oxalamide ethylester I. The synthesized substances showed an antianaphylactic activity.