PHARMACOKINETICS OF THE NEW ANTIARRHYTHMI C AGENT Z-2-AMINO-5-CHLOROBENZOPHENONEAMIDINOHYDRAZONE ACETATE (AWD-G256)

In 4 studies blood levels and metabolites of -amino-5-chlorobenzopheno neamidinohydrazoneacetate (AWD-G256) after different dosages and forms of application on patients and healthy volunteers were investigated. In addition the pharmacokinetic parameters were calculated. The determ ination of pharmacokinetic parameters was possible only after i.v. app lication of dosages higher than 0.30 mg , kg-1 b.m. as well as p.o. ad ministration of dosages higher than 100 mg. The blood level curve afte r i.v. application demonstrated a 2-compartment model and after p.o. a pplication a 1-compartment model. Exact pharmacokinetic data can't be clear estimated with this studies.