THE PREPARATION OF TRITIATED E-4-AMINOBUT-2-ENOIC AND Z-4-AMINOBUT-2-ENOIC ACIDS, CONFORMATIONALLY RESTRICTED ANALOGS OF THE INHIBITORY NEUROTRANSMITTER 4-AMINOBUTANOIC ACID (GABA)

Authors
DUKE RK ALLAN RD DREW CA JOHNSTON GAR MEWETT KN LONG MA THAN C
Citation
Rk. Duke et al., THE PREPARATION OF TRITIATED E-4-AMINOBUT-2-ENOIC AND Z-4-AMINOBUT-2-ENOIC ACIDS, CONFORMATIONALLY RESTRICTED ANALOGS OF THE INHIBITORY NEUROTRANSMITTER 4-AMINOBUTANOIC ACID (GABA), Journal of labelled compounds & radiopharmaceuticals, 33(6), 1993, pp. 527-540
Citations number
35
Categorie Soggetti
Chemistry Analytical","Pharmacology & Pharmacy
Journal title
Journal of labelled compounds & radiopharmaceuticals → ACNP
ISSN journal
03624803
Volume
33
Issue
6
Year of publication
1993
Pages
527 - 540
Database
ISI
SICI code
0362-4803(1993)33:6<527:TPOTEA>2.0.ZU;2-D
Abstract
A synthesis of [H-3]E- and [H-3]Z-4-aminobut-2-enoic acids from methyl 4-N-phthalimidobut-2-ynoate by catalytic hydrogenation using tritium gas in the presence of a homogeneous catalyst, tris(triphenylphosphine )rhodium(I) chloride, is reported. HPLC separation of the E- and Z-iso mers, and the saturated analogue, 4-aminobutanoic acid (GABA), is also described.