STEREOSPECIFIC SYNTHESIS OF (2R,3S)-3-AMINO-2-PIPERIDINEACETIC ACID-DERIVATIVES FOR USE AS CONFORMATIONAL CONSTRAINT IN PEPTIDES

Authors
GOMEZMONTERREY I GONZALEZMUNIZ R HERRANZ R GARCIALOPEZ MT
Citation
I. Gomezmonterrey et al., STEREOSPECIFIC SYNTHESIS OF (2R,3S)-3-AMINO-2-PIPERIDINEACETIC ACID-DERIVATIVES FOR USE AS CONFORMATIONAL CONSTRAINT IN PEPTIDES, Tetrahedron letters, 34(22), 1993, pp. 3593-3594
Citations number
9
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
34
Issue
22
Year of publication
1993
Pages
3593 - 3594
Database
ISI
SICI code
0040-4039(1993)34:22<3593:SSO(A>2.0.ZU;2-#
Abstract
Catalytic hydrogenation at 40-degrees-C of the beta-ketoester, obtaine d from Boc-Orn (Z)-OH and ethyl lithioacetate, provides exclusively et hyl S)-3-tert-butyloxycarbonylamino-2-piperidineacetic acid which when suitably protected, can be used for peptide synthesis.