TRANSAMINATION OF FLUORINATED BETA-KETO CARBOXYLIC ESTERS - A BIOMIMETIC APPROACH TO BETA-POLYFLUOROALKYL-BETA-AMINO ACIDS

Authors
SOLOSHONOK VA KIRILENKO AG KUKHAR VP RESNATI G
Citation
Va. Soloshonok et al., TRANSAMINATION OF FLUORINATED BETA-KETO CARBOXYLIC ESTERS - A BIOMIMETIC APPROACH TO BETA-POLYFLUOROALKYL-BETA-AMINO ACIDS, Tetrahedron letters, 34(22), 1993, pp. 3621-3624
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
34
Issue
22
Year of publication
1993
Pages
3621 - 3624
Database
ISI
SICI code
0040-4039(1993)34:22<3621:TOFBCE>2.0.ZU;2-X
Abstract
The base-catalyzed isomerization of N-benzylimines (or enamines) of be ta-polyfluoroalkyl-beta-ketocarboxylic esters cleanly affords the N-be nzylidene derivatives of beta-polyfluoro-beta-aminocarboxylic esters w hich are hydrolyzed to corresponding amino acids in high overall yield s.