INVITRO BIOSYNTHESIS OF PROSTAGLANDINS IN THE WHITE SEA SOFT CORAL GERSEMIA-FRUTICOSA - FORMATION OF OPTICALLY-ACTIVE PGD2, PGE2, PGF2-ALPHA AND 15-KETO-PGF2-ALPHA FROM ARACHIDONIC-ACID

Authors
VARVAS K JARVING I KOLJAK R VAHEMETS A PEHK T MUURISEPP AM LILLE U SAMEL N
Citation
K. Varvas et al., INVITRO BIOSYNTHESIS OF PROSTAGLANDINS IN THE WHITE SEA SOFT CORAL GERSEMIA-FRUTICOSA - FORMATION OF OPTICALLY-ACTIVE PGD2, PGE2, PGF2-ALPHA AND 15-KETO-PGF2-ALPHA FROM ARACHIDONIC-ACID, Tetrahedron letters, 34(22), 1993, pp. 3643-3646
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
34
Issue
22
Year of publication
1993
Pages
3643 - 3646
Database
ISI
SICI code
0040-4039(1993)34:22<3643:IBOPIT>2.0.ZU;2-A
Abstract
The White Sea soft coral Gersemia fruiticosa has been found to convert exogenous arachidonic acid to optically active prostaglandins D2, E2, F2alpha and 15-keto-F2alpha, all of which were also isolated as endog enous constituents from the same coral extracts. This is the first rep ort of in vitro biosynthesis of ''primary mammalian'' prostaglandins i n coral.